| Rank | Location | Area | Total Crashes | Risk Level | Key Factor |
|---|---|---|---|---|---|
| 1 | Ashley Phosphate Rd & I-26 | North Charleston | 629+ | CRITICAL | Heavy traffic, left turns |
| 2 | Rivers Ave (US-52) Corridor | North Charleston | 580+ | CRITICAL | High speed, commercial |
| 3 | US-17 & Main Rd | Johns Island | 445+ | HIGH | Rural speed, poor lighting |
| 4 | Dorchester Rd & Ashley Phosphate | North Charleston | 410+ | HIGH | Complex intersection |
| 5 | I-26 & I-526 Interchange | North Charleston | 385+ | HIGH | Merge conflicts, trucks |
| 6 | Savannah Hwy (US-17) & Bees Ferry | West Ashley | 360+ | HIGH | Volume, signal timing |
| 7 | US-17 (ACE Basin) | Colleton/Charleston | 320+ | HIGH | Rural 2-lane, DUI |
| 8 | Meeting St & Morrison Dr | Downtown | 290+ | MODERATE | Pedestrian conflicts |
| 9 | Sam Rittenberg & Old Towne | West Ashley | 270+ | MODERATE | Offset intersection |
| 10 | Clements Ferry Rd | Daniel Island | 250+ | MODERATE | Rapid development |
| 11 | Glenn McConnell Blvd & Bees Ferry | West Ashley | 240+ | MODERATE | School zone, volume |
| 12 | US-17 & SC-41 | Mt. Pleasant | 230+ | MODERATE | High-speed merge |